ProSci Inc. offers an extensive range of antibodies and supporting tools to research TIGIT Immune Checkpoint. Read more about their range below, or click a link to jump to a specific section:
- Risk-Free™ Monoclonal TIGIT Products
- Risk-Free™ Single Domain Monoclonal TIGIT Products
- Related Products
- Additional TIGIT Antibody Products
- Additional TIGIT Information
The T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the PVR (poliovirus receptor) family of immunoglobin proteins. Similar to other immune checkpoint proteins such as PD-1, TIGIT is upregulated on exhausted T cells in chronic viral infections and cancer. Blockade of both TIGIT and PD-1 pathways leads to tumor rejection in mice suggesting that it may be of therapeutic use against cancer.
Risk-Free™ Monoclonal TIGIT Products
ProSci’s Risk-Free™ antibodies are monoclonal antibodies made to improve in vivo studies. Unlike antibodies developed using proteins made in yeast or bacteria, Risk-Free™ antibodies are developed with antigens expressed in mammalian cell lines, giving the most native post-translational modifications to the protein. Risk-Free™ means they are guaranteed to work for their approved applications.
Risk-Free™ Mouse Monoclonal TIGIT Set
ProSci’s Risk-Free™ Sets consists of several mAbs with different binding features allowing selection of the best clone.
| Product Set | Size | Contents | Description |
|---|---|---|---|
| Risk-Free TIGIT Set (PSI-RF16050) | 20ug / Clone | PSI-RF16051, PSI-RF16054, PSI-RF16055, PSI-RF16056, PSI-RF16057, PSI-RF16058 | TIGIT antibodies were raised against the extracellular domain of human TIGIT. |
Risk-Free™ Mouse Monoclonal TIGIT Antibodies
ProSci Risk-Free™ TIGIT products are rigorously tested and guaranteed to work for their designated applications.
| Cat. No. | ELISA | WB | ICC | IF | IHC | Flow | Conjugation |
|---|---|---|---|---|---|---|---|
| PSI-RF16051 | + | - | ++++ | ++++ | ++++ | ++++ | Available |
| PSI- RF16053 | + | - | +++ | +++ | +++ | ++++ | Available |
| PSI-RF16054 | ++++ | +++ | ++++ | ++++ | ++++ | ++++ | Available |
| PSI-RF16055 | ++++ | +++ | ++++ | ++++ | ++++ | ++++ | Available |
| PSI-RF16056 | ++++ | ++++ | ++++ | ++++ | ++++ | ++++ | Available |
| PSI-RF16058 | ++ | - | +++ | +++ | +++ | ++++ | Available |
Risk-Free™ Single Domain Monoclonal TIGIT Products
Llama single domain antibodies (sdAbs) offer unique characteristics amenable to many applications. These sdAbs demonstrate low nanomolar binding affinity and can be used for the various applications. Note: TIGIT single domain antibody should be stored in working aliquots at -20 °C, stable for up to one year. As with all antibodies, care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Related products
Antigens
| Cat. No. | Product Type | Species | Tissue/Cell | Datasheet |
|---|---|---|---|---|
| PSI-RF16050-01 | Recombinant Protein | Human | HEK293 |
Lysates
| Cat. No. | Product Type | Species | Tissue/Cell | Datasheet |
|---|---|---|---|---|
| PSI-RF10001-03 | Positive Control (Tissue Lysate) | Human | Spleen | |
| PSI-RF10001-02 | Negative Control (Cell Lysate) | Human | HEK293 |
Slides
| Cat. No. | Product Type | Species | Tissue/Cell | Datasheet |
|---|---|---|---|---|
| PSI-RF10002-02 | Positive Control (Tissue) | Human | Spleen | |
| PSI-RF10002-03 | Negative Control (Cells) | Human | HEK293 |
Conjugates
| Cat. No. | HRP | Biotin | Custom |
|---|---|---|---|
| PSI-RF16051 | Inquire | Contact Us | |
| PSI-RF16053 | Inquire | Contact Us | |
| PSI-RF16054 | Inquire | Contact Us | |
| PSI-RF16055 | Inquire | Contact Us | |
| PSI-RF16056 | Inquire | Contact Us | |
| PSI-RF16058 | Inquire | Contact Us |
Additional TIGIT Antibody Products
Monoclonal antibodies are highly specific and recognize only one epitope on an antigen which generates consistent performance in quantitative detection applications regardless of production batch. Polyclonal antibodies have high affinity and recognize different epitopes on a specific antigen. Note: These antibodies can be stored at -20˚C and are stable for up to one year. Antibodies should not be exposed to prolonged high temperatures.
TIGIT Monoclonal Products
| Cat. No. | Name | Applications | Datasheet |
|---|---|---|---|
| PSI-77-084 | TIGIT Antibody [1G9] (PE) | Flow | |
| PSI-77-086 | TIGIT Antibody [1G9] (APC) | Flow |
TIGIT Polyclonal Products
| Cat. No | Antigen Range | ELISA | WB | ICC | IF | IHC | Flow | Datasheet |
|---|---|---|---|---|---|---|---|---|
| PSI-61-342 | 12 - 142 | 0 | ++++ | 0 | 0 | 0 | 0 |
TIGIT Recombinant Protein Products
| Cat. No. | Sequence | Fusion Tag | Species | Tissue/Cell | Datasheet |
|---|---|---|---|---|---|
| PSI-92-456 | Met 22 - Pro 141 | C-6 His Tag | Human | Human | |
| PSI-92-550 | Gly 26 - Phe 135 | C-6 His Tag | Mouse | Human | |
| PSI-96-722 | Met 22 - Pro 141 | C-Fc Tag | Human | HEK293 |
Additional TIGIT Information
- Genecards: TIGIT Database
- Blog: Problems With Immunotherapy
- Flyer: Immune Checkpoints
- What is Immune Checkpoint Therapy?
ProSci products are distributed across Europe by Caltag Medsystems. If you have any questions about the products in this blog, please contact us.