General Information

Protein Phosphorylation: Essential Role in the Proper Functioning of Pathways

MBLI offers Assay/Inhibitor screening kits designed to measure the activities of purified kinase for the rapid and sensitive evaluation of inhibitors.

S100 Proteins Regulate Metabolic and Immune Pathways to Influence Disease State

Involved in diverse cellular pathways & diseases, S100 proteins play a vital role in intricate workings of cells. MBL has a variety of S100 ELISA kits.

Leveraging Anti-Integrin αvβ6 Antibodies for Ulcerative Colitis

MBLI is proud to introduce the Anti-Integrin αvβ6 ELISA Kit that readily allows measurement of anti-integrin αvβ6 antibody levels in human serum.

IL-18 Therapies Targeting Inflammatory Disease

MBL International offers a wide variety of products to help in the research of IL-18.

CD1d Tetramers for Monitoring Invariant Natural Killer T (iNKT) cells

MBL International offers CD1d tetramers prepared by tetramerisation of complexes of CD1d and β2m by PE- or APC- labelled streptavidin.

New B7 Family Immune Checkpoint Proteins

Recently 5 new B7 family ligands, B7-H3, B7-H4, B7-H5, B7-H6 & B7-H7, were identified, all of them possibly of high interest in immunotherapy research.

HVEM – BTLA – LIGHT – CD160 Network

The checkpoint receptors/ligands system HVEM, LIGHT, CD160 and BTLA (CD272) is part of a complex network of overlapping receptor interactions.

TIGIT – CD155 – CD112 – CD226 Network

Tumour cells exploit the dominance of the inhibitory TIGIT pathway to avoid immune-mediated destruction.

LAG-3 – Major Histocompatibility Complex (MHC) – T Cell Receptor (TCR) Pathway

Dual inhibition of LAG-3 and other checkpoint pathways may synergistically increase T cell antitumour activity.

CTLA-4 [CD152] – CD80 – CD86 – CD28 Network

Targeting CTLA-4 restores immune response by more accumulation, function & survival of T cells, depletion of Tregs & better antitumour response.