Inflammasomes are large multimolecular complexes involved in innate immune and inflammatory responses. A recent study published by the lab of Prof. Victoriano Mulero (Universidad de Murcia, Spain) describes a new function of the inflammasome as a regulator of the balance
OLFR734 Mediates Glucose Metabolism as a Receptor of Asprosin
Asprosin is a fasting-induced hormone that increases plasma glucose levels in the liver. It also stimulates appetite in the hypothalamus by activating the cAMP signaling pathway via an unknown G protein-coupled receptor (GPCR). In a recent study, the lab of
Extracellular Vesicles Containing eNAMPT Extend Lifespan
A recent study published in Cell Metabolism by the lab of Shin-Ichiro Ima (Washington University School of Medicine) shows that the circulating levels of extracellular nicotinamide phosphoribosyltransferase (eNAMPT), a key NAD+ biosynthetic enzyme in mammals, decline with age in mice
Fibrinogen-like Protein 1 (FGL1) – A Major Ligand of LAG-3
LAG-3 is a coinhibitory immune checkpoint receptor that inhibits T cell response by binding to MHC-II. In a recent study published in Cell, the lab of Prof Lieping Chen (Yale University, US) identifies Fibrinogen-like protein 1 (FGL1), a molecule secreted
Protective Role of Irisin in Alzheimer’s Disease
Irisin is a protein cleaved from fibronectin type III domain-containing protein 5 (FNDC5) and has a beneficial role in adipose tissues, bone and brain. A recent study published in Nature Medicine by the labs of O. Arancio, S.Ferreira & F.G.
Manganese (Mn2+) as a New Activator of the NLRP3 Inflammasome in the Brain
Inflammasomes are implicated in physiological and pathological inflammation including neurodegenerative disorders such Parkinson or Alzheimer diseases. Divalent manganese (Mn2+) activates chronic inflammation leading to increase of neurotoxicity. Recently, the lab of A.G. Kanthasamy (Iowa State University, US) showed that Mn2+ activates
Erythroferrone (human) ELISA Kit – The only Specific & Sensitive Assay on the Market!
Sandwich ELISA Kit based on two antibodies for the in vitro quantitative determination of human Erythroferrone in supernatants, serum and plasma.
Apoptosis Detection Kits
In general, early apoptosis can be determined by Mitochondrial membrane ΔΨm assay, Annexin V-FITC/PI assay and Caspase-3 assay. Late apoptosis can be determined by TUNEL, DNA ladder assay and DNA content analysis. Elabscience® provides simple and sensitive solutions for detection
CML Green Initiative: Where to start…
When someone mentions that we should be doing more to save the planet, it is often met with a groan (do I really have to separate my food waste?). In a commercial setting, it can be hard to gain momentum
Innovative Applications of TransFix®
TransFix® is designed for stabilisation of peripheral blood and cerebrospinal fluid to enumerate lymphocyte subpopulations by flow cytometry. However, researchers have developed many new and innovative uses of TransFix. We’ve presented a selection of publications to highlight the versatility of